Neurogenomics and Neuronal Physiopathology

The focus on glutamatergic signaling and metabolism is supported by previous accumulated evidence from the team reporting various genetic alterations affecting the structure, the development and/or the function of excitatory glutamatergic neuronal connections in patients with neurodevelopmental disorders (ID and/or autism), as well as abnormal molecular signatures supporting perturbations in glutamate initiated signaling pathways and converging towards glutamate‐mediated excitotoxicity in ALS.