[PUBLICATION] Enhanced Macromolecular Substance Extravasation through the Blood-Brain Barrier via Acoustic Bubble-Cell Interactions

Date(s)

du 22 janvier 2024 au 19 février 2024

Une publication de Jufa Chen, et Ayache Bouakaz en collaboration avec l'unité INSERM N2C et Zhejiang University (Zhejiang, Chine).

Highlights

The application of ultrasound and microbubbles (US + MBs) enhances the extravasation of macromolecular substance through blood–brain barrier via transcytosis mechanism.
The mechanical interaction between oscillating microbubbles and cell membranes results in direct membrane deformation and generates both mechanical and sonochemical effects.
The formation of pits on the cellular membrane surface is a critical step in the initiation of endocytosis or transcytosis processes.
US + MBs application induced membrane hyperpolarization and increase of cytosolic calcium concentration.
Mechanical interaction between oscillating microbubbles and cell membrane plays a necessary role in the dynamin-/caveolae-/clathrin- related transcytosis.

You can access the manuscript here. (Open Access)

Contact :