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[PUBLICATION] Bubbles, Droplets and Micelles for Acoustically-Mediated Drug/Gene Delivery

  • Recherche,
  • Santé-Sciences-Technologie,
  • Santé-social,
Editorial: Bubbles, Droplets and Micelles for Acoustically-Mediated Drug/Gene Delivery
Editorial: Bubbles, Droplets and Micelles for Acoustically-Mediated Drug/Gene Delivery
Date(s)

le 21 août 2020

Published in Front Pharmacol

Editorial co-written by Dr. Jean-Michel Escoffre

Bubbles, Droplets and Micelles for Acoustically-Mediated Drug/Gene Delivery

Editorial on the Research Topic

This special issue presents novel contributions from 86 authors in a compilation of nine original articles and two review articles: four articles from Asia, three from America, and four from Europe. The issue presents findings in the fields of bactericidal therapy, cancer, inner-ear diseases, and underlying mechanisms of ultrasound-mediated drug/gene delivery, all of them with a clear goal: clinical translation. All findings reported in this issue had 8,517 views on April 10th 2020 (source of counting: Frontiers in Pharmacology).

Therapeutic ultrasound shows promising findings in ultrasound-mediated nitric oxide (NO) delivery using lipid-shelled nitric oxide-loaded microbubbles. NO is a potent bioactive gas that was evidenced to display biofilm dispersion and bactericide properties; its delivery in specific anatomical regions is increasingly investigated (Elnaggar et al., 2017), and paves the way for novel encapsulation formulations. In this issue, Lafond and colleagues report on an in vitro proof-of-concept demonstrating the relevance to co-encapsulate octafluoropropane in a microbubble formulation containing NO (Lafond et al.). The authors showed an increased payload loading, compatible acoustic properties using a clinical ultrasound scanner, and a significant increase in bacterial killing [Read more].

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