Dysfonctions neurologiques chez les enfants autistes

  • Santé-Sciences-Technologie,

du 14 avril 2018 au 22 avril 2018

Published in J. Clin. Med.

Projet de recherche collaborative dirigé par le Prof. Roccella (University of Palermo) auquel le Prof. Bonnet-Brilhault et le Dr. Sylvie Roux ont participé

Minor Neurological Dysfunctions (MNDs) in Autistic Children without Intellectual Disability


Children with autism spectrum disorder (ASD) require neurological evaluation to detect sensory-motor impairment. This will improve understanding of brain function in children with ASD, in terms of minor neurological dysfunctions (MNDs).


We compared 32 ASD children without intellectual disability (IQ ≥ 70) with 32 healthy controls. A standardized and age-specific neurological examination according to Touwen was used to detect the presence of MNDs. Particular attention was paid to severity and type of MNDs.


Children with ASD had significantly higher rates of MNDs compared to controls (96.9% versus 15.6%): 81.3% had simple MNDs (p < 0.0001) and 15.6% had complex MNDs (p = 0.053). The prevalence of MNDs in the ASD group was significantly higher (p < 0.0001) than controls. With respect to specific types of MNDs, children with ASD showed a wide range of fine manipulative disability, sensory deficits and choreiform dyskinesia. We also found an excess of associated movements and anomalies in coordination and balance.


Results replicate previous findings which found delays in sensory-motor behavior in ASD pointing towards a role for prenatal, natal and neonatal risk factors in the neurodevelopmental theory of autism.
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