Actualité

[PUBLICATION] Mutltifaceted Biological Roles of Leptin

  • Recherche,
  • Santé-Sciences-Technologie,
  • Santé-social,
Date(s)

le 8 juillet 2020

Collaborative research project led by Prof. Jean-Philippe Bastard (Hôpitaux universitaires Henri Mondor, AP-HP, Département de biochimie-pharmacologie-biologie moléculaire-génétique médicale, Créteil, France) in which Dr. Diane Dufour-Rainfray participated

Mutltifaceted Biological Roles of Leptin

Abstract

The identification of leptin allowed the discovery of a new endocrine system. This major adipokine controlling energy homeostasis is also involved in the regulation of neuroendocrine function and fertility. Unfortunately, leptin is not able to treat common obesity, which associates hyperleptinemia and resistance to the hormone. Conversely, treatment with recombinant leptin is effective in situations of leptin deficiency. Several pathophysiological situations associated with adipose tissue dysfunctions and abnormal regulation of leptin secretion are discussed in this review. The advantage of the potential use of the leptin assay in some pathophysiological conditions is proposed.

Keywords

#Cancer #dementia #fertility #leptin #metabolicsyndrome #obesity

Contact :
Dr. Diane Dufour-Rainfray :