Corrélation entre le polymorphisme du gène HTR2B et la dépendance au crack
- Pharmacie,
- Recherche,
- Santé-Sciences-Technologie,
- Santé-social,
le 11 janvier 2019
Projet de recherche collaborative dirigé par le Prof. F. Thibault (Inserm UMR 894, Center of Psychiatry and Neuroscience, University Hospital Cochin, Paris, France) auquel le Prof. Nicolas Ballon a participé
A positive association between a polymorphism in the HTR2B gene and cocaine-crack in a French Afro-Caribbean population
Abstract
Objectives - Cocaine dependence has a strong heritability component. The aim of this study was to investigate the putative association between the serotonin 2B receptor gene (HTR2B), crack use disorders and impulsivity.
Methods - A French Afro-Caribbean male population of patients with crack use disorders (n = 80) was compared to healthy Afro-Caribbean male controls (n = 60). Comorbid ADHD and impulsivity were assessed. Five single nucleotide polymorphisms in the HTR2B gene were selected: rs643700, rs6736017, rs1549339, rs17586428 and rs3806545 These SNPs were chosen to include most of the linkage disequilibrium (LD) blocks in the HTR2B gene. The French translation of the Baratt Impulsivity Scale BIS-11 was used to evaluate impulsivity. Comorbid ADHD was diagnosed using the Wender Utah Rating Scale-25 item for the Attention Deficit-Hyperactivity Disorder.
Results - We have observed a positive association between the rs6736017 polymorphism and crack use disorders in a French Afro-Caribbean male population.
Conclusion - In our population, the risk effect of HTR2B rs6736017 appeared to be specific to individuals with crack use disorders rather than being driven by impulsivity or ADHD alone.
Keywords
ADHD; HTR2B gene; cocaine use disorders; crack; impulsivity.
#crack #ADHD #HTR2B #cocaine #psychiatry
