Actualité

Clinical guidelines for the management of treatment-resistant depression

  • Recherche,
  • Santé-Sciences-Technologie,
  • Santé-social,
Date(s)

le 15 octobre 2019

Published in BMC Psychiatry

Projet de recherche collaborative dirigé par le Prof. E. Haffen (Service de Psychiatrie clinique, Centre Expert Dépression Résistante FondaMental, Centre Investigation Clinique 1431-INSERM, EA 481 Neurosciences, Université de Bourgogne Franche Comté, Besançon, France) auquel les Profs. El-Hage et Camus ont participé

Clinical guidelines for the management of treatment-resistant depression: French recommendations from experts, the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental

Abstract

BACKGROUND: Clear guidance for successive antidepressant pharmacological treatments for non-responders in major depression is not well established.

METHOD: Based on the RAND/UCLA Appropriateness Method, the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental developed expert consensus guidelines for the management of treatment-resistant depression. The expert guidelines combine scientific evidence and expert clinicians' opinions to produce recommendations for treatment-resistant depression. A written survey comprising 118 questions related to highly-detailed clinical presentations was completed on a risk-benefit scale ranging from 0 to 9 by 36 psychiatrist experts in the field of major depression and its treatments. Key-recommendations are provided by the scientific committee after data analysis and interpretation of the results of the survey.

RESULTS: The scope of these guidelines encompasses the assessment of pharmacological resistance and situations at risk of resistance, as well as the pharmacological and psychological strategies in major depression.

CONCLUSION: The expert consensus guidelines will contribute to facilitate treatment decisions for clinicians involved in the daily assessment and management of treatment-resistant depression across a number of common and complex clinical situations.
Keywords

#Antidepressants; #Expert consensus guidelines; #Major #depressive #disorder; #Pharmacotherapy; #Treatment #resistant #depression

Contact :
Prof. Vincent Camus :